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Dr. Mario's Virus Buster is a WiiWare game. It is like the other Dr. Mario games, except that the player can replace Dr. Mario with a Mii. It costs 1,000 Wii Points in America. This game is the first game to feature Miis that talk. The game is based on the event in where Dr. Mario opened the Mii Hospital and allowed a few Miis to become doctors for the first time.

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